14Mar
CPIN Distinguished Visiting Neuroscientist Lecture of interest by Carlos Brody (Princeton)
The following talk may be of interest to KCNhubbers and the computational neuroscience community. The 2023-2024 CPIN Julius Axelrod Distinguished Visiting Neuroscientist Lecture entitled "Towards cross-brain neural recordings, analyses, and modeling", will be given by Dr. Carlos Brody (Princeton) on Thursday March 14th at 4pm, MSB.

13Mar
Minisymposium on Computational Neuroscience to be held at CAIMS Meeting
This year's Canadian Applied and Industrial Mathematics Society (CAIMS) Meeting will include a Computational Neuroscience minisymposium.

28Feb
KCNhub member Dr. Frances Skinner publishes an Insight article
Building a mathematical model of the brain: Automatic leveraging of information in a hippocampal neuron database to generate mathematical models should help foster interactions between experimental and computational neuroscientists.

17Nov
Center for Mathematical Medicine (CMM) Seminar of interest by Anmar Khadra
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It is part of the Fields/CMM seminar series - see 'Training/Seminars' tab. The speaker is Professor Anmar Khadra (McGill University), whose talk is entitled: "Unraveling the Complex Interaction between Axons, Myelin, and Oligodendrocytes through Computational Modeling". The talk is on Friday, November 17 at 12:30pm. The seminars will be in hybrid format (as usual) - in person in Room 210 at the Fields Institute or join via https://zoom.us/j/99786422622).

25Oct
KCNhub member Dr. Nooshin Bahador receives a Brain Canada Award
Congratulations! Dr. Nooshin Bahador has received a Brain Canada Rising Stars Award.

6Oct
Tanz CRND Talk of interest by KCNhub member Dr. Maurizio De Pitta
On Friday Oct 6th, noon-1pm, Dr. Maurizio De Pitta will be a guest speaker at the Tanz CRND seminar series (hybrid).

5Oct
The fourth edition of the Canadian Computational Neuroscience Spotlight (CCNSv4) will take place on Oct 5-6
This CCNS meeting continues an organizational Krembil^2 collaboration and will once again take place entirely virtually using the Crowdcast platform. CCNSv4 will be a “sibling meeting” to the Krembil Computational Neuroscience Symposium taking place (in person in Toronto) on October 2-3.

3Oct
KCN Symposium - DAY 2 Agenda
Agenda for Day 2 of the Krembil Computational Neuroscience (KCN) Symposium

2Oct
KCN Symposium - DAY 1 Agenda
Agenda for Day 1 of the Krembil Computational Neuroscience (KCN) Symposium

28Sep
UHN news highlight of KCNhub research - Lefebvre and Valiante labs
The research of KCNhub members, alumnus and collaborator on 'diversity and resilience' was highlighted in a recent UHN news highlight write-up, which can be found following the link below.

28Sep
KCNhub member Dr. Milad Lankarany receives a Brain Canada Award
Congratulations! Dr. Milad Lankarany has received an award from the Future Leaders in Canadian Brain Research Program.

27Sep
New KCNhub logo launched!
Thank you and merci beaucoup Twayne!

19Sep
Mini-symposium on Glia in Neurodegeneration
KCNhub member Dr. Maurizio De Pitta is hosting a minisymposium with Dr. Gabor Kovacs on Tues September 19th.

13Sep
CRANIA Conference 2023
Upcoming CRANIA Conference 2023 will take place on Wednesday, Sept 13, 2023 at 81 Bay St, CIBC Square - Microsoft Conference Centre. The conference promises to be an exciting gathering of brilliant minds, fostering collaboration and innovation in our field. See more info for tentative agenda.

13Sep
Mark your calendars for our Krembil Computational Neuroscience (KCN) Symposium on Oct 2-3
Our KCN Symposium, Mathematical bridges for the brain: Theory and practice in neural health and disease, will take place at the BMO Education and Conference Center on Oct 2-3, 2023 (IN PERSON).

17Aug
KCNhub member Dr. Milad Lankarany receives CIHR Operating Grant
Congratulations! Dr. Milad Lankarany has success at the Spring 2023 competition of the CIHR Project Grant Program.

16Aug
KCNhub members Drs. Homeira Moradi, Frances Skinner, Taufik Valiante, and KCNhub alumni Dr. Scott Rich and Happy Inibhunu publish new paper
The direct study of human neurons, the fundamental unit of the nervous system, has rapidly advanced the understanding of what makes the human brain unique. A vital next step in this endeavor is connecting the distinguishing features of these neurons to the distinctive dynamics of the human brain at larger scales. Here, Inibhunu et. al. showcase the utility of computational tools in this pursuit, using detailed models to relate specific micro-level features of human neurons to a viable mechanism explaining oscillatory activity in the human cortex.

31Jul
KCNhub members Dr. Aref Pariz, Daniel Trotter and Dr. Jeremie Lefebvre publish new paper with colleague and Daniel Trotter
By having variability in intrinsic neuronal timescales, i.e. membrane time constant, it is feasible to engage spike-timing-dependent plasticity (STDP) and control synaptic connectivity with periodic stimulation. This study offers exciting possibilities for guiding plasticity across cortical layers, through non-invasive brain stimulation techniques.

31Jul
KCNhub members Mohammad Rezaei and Dr. Milad Lankarany publish new paper with colleagues
We propose a new model, the heterogeneous input discriminative-generative decoder (HI-DGD) model, which utilizes neural activities and behavioral signals to infer cognitive states related to conflict and non-conflict decision-making in Parkinson's disease patients. The HI-DGD model outperformed traditional methods, identifying significant neural features contributing to conflict processing and highlighting its potential for closed-loop neuromodulation systems.

31Jul
KCNhub members Mohammad Rezaei and Dr. Milad Lankarany publish new paper with colleagues
We presented a computational framework demonstrating how an ensemble of homogeneous neurons can achieve synchrony-division multiplexing (SDM), allowing them to encode multiple features of a mixed stimulus. The study showed that slow and fast features of the stimulus can be inferred from the spikes generated by the ensemble, and the model revealed that the homogeneous neural ensemble can perform both temporal- and rate-coding functions simultaneously.

31Jul
KCNhub members Yupeng Tian, Drs. Luka Milosevic and Milad Lankarany publish new paper with colleagues
We developed a model to investigate the physiological mechanisms underlying the firing rate dynamics of basal ganglia and thalamic neurons in response to different frequencies of DBS.

31Jul
KCNhub members Drs. Nooshin Bahador and Milad Lankarany publish new paper
The attention mechanism in neural network models, originally designed for NLP, plays a crucial role in understanding the dynamics and stability of complex systems by identifying nodes involved in imbalanced structures and polarity-driven structural instabilities, which can lead to dramatic changes in network dynamics.

31Jul
KCNhub members Dr. Nooshin Bahador, Josh Saha, Mohammad Rezaei and Dr. Milad Lankarany publish new paper with colleagues
DBS is a widely used treatment for movement disorders and cognitive neuroscience. This study proposes a new method to remove DBS artifacts from neural recordings by combining SVD and normalized adaptive filtering.

24Jul
KCNhub members Drs. Jeremie Lefebvre and Taufik Valiante, and KCNhub alumnus Dr. Scott RIch publish new paper with colleague
The relationship between heterogeneity (variability in excitability within a population of neurons) and resilience was analyzed both analytically and numerically. From this, the fundamental role played by cell-to-cell heterogeneity in the robustness of brain function in the face of change is highlighted.

27Jun
KCNI Annual Open House
The Krembil Centre for Neuroinformatics’ Annual Open House is taking place on Tuesday, June 27, 2023 between 10 am to 2 pm.

26Jun
KCNhub member Yijinmide Buren receives Krembil research day award
Congratulations Yiji and to all KCNhub members who presented at Krembil Research Day this year (nice to be physical again!). See more info for details from Krembil admin.

25Jun
KCNhub member Zhenyang Sun receives NSERC Scholarship Award
Congratulations! Zhenyang has been awarded an NSERC CGSM Scholarship Award for 2023-24 for his project on modeling astrocytes as supervised by Dr. Maurizio De Pitta.

25May
Krembil Neuroinformatics Talk of interest by Dr. Liisa Galea
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

2May
Krembil Neuroinformatics Talk of interest by Dr. Gillian Strudwick
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

24Mar
KCNhub member Zhenyang Sun receives travel award to attend CAN Meeting
Zhenyang Sun working in Dr. Maurizio De Pittà's lab has obtained a travel award to attend the Canadian Neuroscience Meeting (CAN) in Montreal in May 2023. Congratulations!

23Mar
Krembil Neuroinformatics Talk of interest by Dr. Jed Meltzer
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

1Mar
KCNhub members David Crompton, Drs. Milad Lankarany and Frances Skinner and colleagues publish new paper
The authors conceptualize and use a robust adaptive unscented Kalman Filter (RAUKF) methodology with conductance-based neuron models. They show that parameters can be estimated in a real-time fashion despite model mismatches and variation in initial conditions. This opens up the field for parameter state estimation of biophysical parameters directly from experimental recordings.

28Feb
Krembil Neuroinformatics Talk of interest by Dr. Sarah Goodday
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

8Feb
KCNhub members Zhenyang Sun, David Crompton and Drs. Milad Lankarany and Frances Skinner publish new paper
The authors use a detailed cellular model of a hippocampal interneuron (OLM cell) to create a reduced model that maintains biophysical fidelity and captures complex output of spiking resonance of the detailed model. They undertake extensive analyses with the reduced model that subsequently predicts that a combination of h- and M-channel biophysical characteristics is what allows spiking resonance to occur at theta frequencies specifically in OLM cells in vivo. This theta resonance likely plays an essential role in the generation of theta rhythms in the hippocampus. The reduced model is further exploited to show that it is possible to directly extract conductance parameter values from current clamp recordings in real time using Kalman filter algorithms.

26Jan
Krembil Neuroinformatics Talk of interest by Dr. Gerold Schmitt-Ulms
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

18Nov
Center for Mathematical Medicine (CMM) Seminar of interest by Silvia Budday
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It is part of the Fields/CMM seminar series - see 'Training' tab. CMM seminar at 12:15pm, Friday, November at 12:15pm. The seminar will be in hybrid format (as with all CMM seminars this year). In person in Room 210 at the Fields Institute, or via Zoom - you have to register on the CMM-Fields website to get the Zoom link.

18Nov
Science Talk of interest by KCNhub member Daniel Trotter
Faculty of Science at URegina for LGBT STEM day this Friday (Nov 18) at 4:45 PM Eastern time. It's open to anyone who is interested to attend online. See 'more info' for details.

3Nov
UHN research news highlight of KCNhub research - De Pittà lab
The research of Drs. Maurizio De Pittà and Nicola Brunel expose glia's role in cognitive processing, as highlighted in a recent UHN research news writeup which can be found following the link below

27Oct
Krembil Neuroinformatics Talk of interest by Dr. Bengi Baran
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

27Oct
Department of Physiology (Univ Toronto) news highlight of KCNhub research - De Pittà lab
KCNhub member Dr. Maurizio De Pittà highlighted in a Department of Physiology news writeup which can be found following the link below

26Oct
UHN news highlight of KCNhub research - De Pittà lab
The research of KCNhub member Dr. Maurizio De Pittà and colleague of glia's role in cognitive processing was highlighted in a recent UHN news writeup which can be found following the link below

25Oct
KCNhub member Dr. Maurizio De Pittà and colleague publish new paper
The authors propose that glia could underpin working memory, introducing models of cortical neuron–glial networks where synapse–glia signaling could account for firing and silent working memory encoding. Their theory can explain emerging accounts of the variegated nature of working memory encoding and the possible contribution of glia to it.

19Oct
Mathematical Neuroscience Talk of interest by KCNhub member Dr. Afroditi Talidou
Hybrid talk being given by Dr. Afroditi Talidou in the Department of Mathematics, University of Ottawa. See 'more info' for details.

13Oct
KCNhub alumnus Alireza Ghadimi and KCNhub members Leon Steiner, Drs. Luka Milosevic and Milad Lankarany and collaborator publish new paper
The authors develop a novel dual optimization method that can determine parameters for short-term plasticity models with different deep brain stimulation frequencies.

4Oct
KCNhub members Drs. Afroditi Talidou and Jeremie Lefebvre and collaborators publish new paper
The authors studied the effects of activity-dependent myelination (ADM) on network activity and information transmission in the brain. They found that ADM implements a homeostatic gain control mechanism that enhances neural firing rates and correlations through the temporal coordination of action potentials as axon lengths increase. Moreover, ADM enhances information transmission under various types of time-varying stimuli. These results highlight the role of ADM in shaping neural activity and communication.

28Sep
KCNhub members Drs. Luka Milosevic and Taufik Valiante and colleague receive CFI JELF Award
Congratulations! Drs. Luka Milosevic, Suneil Kalia and Taufik Valiante are one of five UHN research teams to have received Canada Foundation for Innovation’s John R. Evans Leaders Fund (JELF) for research infrastructure.

16Sep
Center for Mathematical Medicine Seminar of interest by Alain Goriely
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It is part of the Fields/CMM seminar series - see 'Training' tab.

14Sep
Krembil Neuroinformatics Talk of interest by Dr. Ryan Smith
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

24Aug
Krembil Neuroinformatics Talk of interest by Dr. Angela Laird
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

19Aug
KCNhub member Dr. Milad Lankarany receives JP Bickell Medical Research Award
Congratulations! Dr. Milad Lankarany has received a 2022-23 Award from the JP Bickell Foundation.

8Aug
KCNhub members Drs. Jeremie Lefebvre and Taufik Valiante publish in 'The Conversation'
What epilepsy teaches us about diversity and resilience - as written in The Conversation - an independent source of news and views, from the academic and research community, delivered direct to the public.

19Jul
KCNhub member Dr. Maurizio De Pitta, organizer of latest advances in Computational and Experimental Glioscience Workshop, at Annual Computational Neuroscience Meeting
Dr. De Pitta has organized a workshop at the Annual Computational Neuroscience Meeting (CNS2022) that will take place in Melbourne, Australia on July 19-20. The workshop is entitled, Emerging Perspectives and Models for Neuron-Glial Interactions. Speakers include KCNhub members Drs De Pitta and Jeremie Lefebvre.

19Jul
KCNhub member Dr. Afroditi Talidou to present at the Annual CNS2022 Meeting
Dr. Afroditi Talidou is one of the speakers at a workshop at the Annual Computational Neuroscience Meeting (CNS2022) that will take place in Melbourne, Australia on July 16-20. The workshop is entitled, White matter, axons, and the role of delays – modeling axonal transmission.

16Jul
KCNhub member Dr. Maurizio De Pitta, organizer of Computational Glioscience Tutorial, at Annual Computational Neuroscience Meeting
Dr. De Pitta has organized a tutorial session at the Annual Computational Neuroscience Meeting (CNS2022) that will take place in Melbourne, Australia on July 16, 2022. The tutorial is entitled, Modeling Neuron-Glial Interactions. In addition to Dr De Pitta, KCNhub members Drs. Jeremie Lefebvre, Afroditi Talidou and Daniel Park are speakers in the tutorial.

9Jul
KCNhub member Dr. Taufik Valiante publishes new paper with KCNhub alumni members and collaborators
The authors characterize single-unit activity during saccadic eye movements in the human mesial temporal lobe and demonstrate that this activity contains directional information and is inhibitory. These findings lead them to conclude that human memory structures receive a corollary discharge mediated by a circuit including the nucleus reuniens.

27Jun
Computational Neuroscience Talk of interest: MPUTC Lecture by Dr. Michael Yassa
The following lecture is an event in the Max-Planck-University of Toronto Center for Neural Science and Technology. It is of interest to the KCNhub community. Click "more info" for details!

24Jun
KCNI Annual Open House
The Krembil Centre for Neuroinformatics’ Annual Open House is taking place on Friday, June 24, 2022 between 10 am to 4 pm.

6Jun
The third edition of the Canadian Computational Neuroscience Spotlight, co-organized by KCNhub members Dr. Scott Rich and Dr. Milad Lankarany, will take place June 6-7
CCNSv3 will include sessions on Neural Circuit Modeling (chaired by KCNhub alumnus Dr. Alexandra Chatzikalymniou), Large-Scale Brain Modeling, Neuro-AI, and Cognitive Modeling. Details can be found at ccnsmeeting.ca, click "more info" below for a link to the registration page.

2Jun
Krembil^2 Retreat
The Krembil Centre for Neuroinformatics at the Centre for Addiction and Mental Health and the Krembil Brain Institute at the University Health Network are hosting a special Krembil² retreat to bring together the two hospitals and its research scientists and establish a formal collaboration between the two institutions. Intended Audience: Researchers, clinicians, and trainees under CAMH and UHN.

25May
Krembil Neuroinformatics Talk of interest by Dr. Jesse Gillis
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

24May
KCNhub members Drs. Scott Rich, Homeira Moradi Chameh, Jeremie Lefebvre and Taufik Valiante publish new paper
This interdisciplinary work highlights that neural heterogeneity is lost in epileptogenic human brain tissue, which renders neural circuits more vulnerable to sudden transitions into synchrony that are a hallmark of seizure onset.

31Mar
Talk of Interest by KCNhub member Dr. Scott Rich at NERCCS 2022
Dr. Scott Rich is an invited speaker at the Fifth Northeast Regional Conference on Complex Systems (see link below for more info). The conference runs March 31 to April 1, and Dr. Rich will give his presentation, entitled "Multistability and bifurcations in epileptogenic neural circuits", at 2:30 pm on April 1. Registration is free!

23Mar
Krembil Neuroinformatics Talk of interest by Dr. Philip Sterzer
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

6Mar
EMBO | EMBL Symposium: Biological oscillators: design, mechanism, function
This symposium (6-9 March, 2022) may be of interest to the KCNhub community given its inclusion of computational neuroscience aspects. KCNhub member (F.K.Skinner) is one of the speakers. Virtual registration deadline - February 24, 2022.

27Jan
KCNhub member Dr. Maurizio De Pitta is a Director of the Organization for Computational Neurosciences
Congratulations! Dr. Maurizio De Pitta has been elected to the Board of Directors of the Organization of Computational Neurosciences (OCNS) for 2022.

17Jan
KCNhub member Dr. Taufik Valiante has a new appointment
Congratulations! Dr. Taufik Valiante appointed as Gerry and Tootsie Halbert Chair in Neural Repair and Regeneration at University Health Network.

7Dec
Are dendrites necessary for cortical computation?
The following workshop may be of interest to the KCNhub community given its focus on computational neuroscience. A Dendrites Virtual Workshop hosted at Emory University Dec. 7. Click "more info" for details!

1Dec
KCNhub member Dr. Scott Rich to present at Neuromatch 4.0
Dr. Rich will be presenting work entitled "Resilience through diversity: Loss of neuronal heterogeneity in epileptogenic human tissue impairs network resilience to sudden changes in synchrony" as a featured short talk at Neuromatch 4.0 on Wednesday, December 1 at 2 p.m. Click "more info" for a link to the abstract and to the site for registration information.

4Nov
UHN news highlight of KCNhub research - Skinner lab
The research of KCNhub members to understand the generation of brain rhythms was highlighted in a recent UHN research news write-up which can be found following the link below.

26Oct
Canadian Symposium for Computational Neuroscience
Campus Alberta Neuroscience is presenting a Canadian Symposium for Computational Neuroscience, being held October 26-27 2021. This may be of interest to the KCNhub community given its focus on computational neuroscience. KCNhub member (F.K.Skinner) is one of the speakers.

25Oct
Krembil Neuroinformatics Talk of interest by Dr. Xiaosi Gu
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

29Sep
Free Online Workshop: Towards multipurpose neural network models II: Model testing and model fitting
This online workshop on Sept 29-Oct 1 organized by A. Arkhipov (Allen Institute) and G. Einevoll (Oslo) may be of interest to the KCNhub community given its focus on computational neuroscience. KCNhub member (F.K Skinner) is a speaker in the workshop.

29Sep
Krembil Neuroinformatics Talk of interest by Dr. Rebecca Hodge
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

16Sep
Computational Neuroscience Talk of interest by Dr. Maurizio De Pittà (KCNhub member)
The following talk in the Physiology Department by Dr. Maurizio De Pittà may be of interest to the KCNhub community given its focus on computational neuroscience. Click "more info" for details!

3Sep
KCNhub member Dr. Luka Milosevic receives Brain Canada award
Congratulations! Dr. Luka Milosevic is one of 20 early career researchers to have received an award from the Future Leaders in Canadian Brain Research Program.

31Aug
KCNhub alumnus Dr. Alexandre Guet-McCreight and KCNhub member Dr. Frances Skinner publish new paper
In this work the authors show how computational models and theoretical analyses can be leveraged to bring together in vitro and in vivo experiments to determine functional contributions of specialized inhibitory cell types in the hippocampus.

23Aug
KCNhub member Dr. Milad Lankarany and collaborators receive Krembil Collaborative Seed Grant
Grant Title: A Translational Computing Framework to Uncover Mechanistic Pathways of Depression in Patients with MDD-Epilepsy via Simultaneous Stimulation and iEEG Recordings.

4Aug
Krembil Neuroinformatics Talk of interest by Dr. Marta Garrido
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

1Aug
KCNhub members Drs. Marjan Rafiee and Taufik Valiante and collaborator publish new paper
In this paper, the authors review how auditory stimulation alters brain dynamics, in addition to computational approaches to define the structural features of classical music, to then propose a plausible mechanism for the underlying anti-convulsant effects of listening to Mozart K.448.

21Jul
Krembil Neuroinformatics Talk of interest by Dr. Blake Richards
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

16Jul
KCNhub members Yupeng Tian, Drs. Idir Mellal, Milad Lankarany and collaborators publish new paper
Textile recorded ECG signals are essential for realizing the day-to-day health monitoring of heart rate variability. By developing a novel model of textile sensor noise, the authors generate standardized textile-ECG datasets to develop, test and validate textile-compatible ECG R-peak detection algorithms.

15Jul
UHN news highlight of KCNhub research - Milosevic and Lankarany labs
The research of KCNhub members and collaborators to provide insights into the effects of DBS stimulation was highlighted in a recent UHN research news write-up which can be found following the link below.

14Jul
KCNhub members Drs. Luka Milosevic, Milad Lankarany and collaborators publish new paper
Despite the established use of deep brain stimulation (DBS) as a therapeutic intervention for disorders such as Parkinson's, essential tremor, and dystonia, the neurophysiological mechanisms of action have remained elusive. In this recent work, we have provided experimental and computational insights into the effects of DBS across various subcortical nuclei in patients undergoing neurosurgery. This work demonstrates that the modulation of single-neuron activity by DBS pulses is site-specific and dependent on the engaged local microcircuitry. Stimulation in structures with predominantly GABAergic inputs leads to inhibition of neuronal activity, while stimulation in structures with predominantly glutamatergic inputs leads to neuronal excitation. Moreover, DBS is frequency-dependent, which is a consequence of the elicitation of short-term synaptic plasticity. Namely, increased stimulation frequencies lead to a site-unspecific convergence towards neuronal suppression, hypothesized to be the result of synaptic depression. The site-specific modulation of neuronal activity by single pulses was modelled as a simultaneous activation of all afferent inputs to stimulation target neurons; each of which was implemented with distributions of inhibitory/excitatory afferent inputs derived from anatomical literature. The frequency-dependence of DBS was modelled by a concurrent implementation of the Tsodyks-Markram model of short-term plasticity, which modulates synaptic efficacy based on the frequency of successive activations. This computational framework, which takes into consideration both anatomical and physiological properties of the the stimulated brain regions, could effectively model experimental data from the human subthalamic nucleus, substantia nigra pars reticulata, thalamic ventral intermediate nucleus, and thalamic reticular nucleus.

12Jul
KCNhub member Dr. Scott Rich receives prize at 21st Annual Krembil Research Day
Annual Krembil Research Day held virtually on June 16th via GatherTown - nice work!

5Jul
KCNhub member Dr. Scott Rich to present at the CNS2021 Online Meeting
Featured Talk entitled: Lost neural heterogeneity in human epilepsy is a fundamental principle unifying epileptic etiologies

21Jun
KCNI's Annual Virtual Open House
The Krembil Center for Neuroinformatics is having its annual virtual open house.

8Jun
UHN news highlight of KCNhub research - Valiante lab
The research of KCNhub members and collaborators to characterize the diverse cell types of the human brain was highlighted in a recent UHN research news write-up which can be found following the link below.

4Jun
KCNhub members Dr. Alexandra Pierri Chatzikalymniou, Melisa Gumus and Dr. Frances Skinner publish new paper
By linking minimal and detailed mathematical models of CA1 hippocampus, the authors are able to distinguish pyramidal cells as the initiators of theta rhythms in the hippocampus and to predict how theta frequencies are controlled.

20May
Computational Neuroscience Talk of interest by Dr. Kim (Avrama) Blackwell
The following talk in the Physiology Department by Dr. Blackwell may be of interest to the KCNhub community given its focus on computational neuroscience. Click "more info" for details!

17May
The second Canadian Computational Neuroscience Spotlight (CCNSv2) begins
Register now for CCNSv2 taking place on May 17-18. Further details at the link.

3May
KCNhub members Drs. Homeira Moradi Chameh, Scott Rich, Taufik Valiante, and collaborators publish new paper
This paper presents one of the largest ever characterizations of the intrinsic properties of human cortical neurons, revealing notable diversity in their properties and distinct features of these neurons when compared to their rodent counterparts.

30Apr
KCNhub member Dr. Afroditi Talidou and collaborators publish new paper
The authors introduce a new geometrical extension of the FitzHugh–Nagumo equations describing propagation of electrical impulses in unmyelinated axons.

26Apr
Krembil Neuroinformatics Talk of interest by Dr. Joel Zylberberg
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

21Apr
KCNhub member Dr. Scott Rich has been awarded the Stériade-Savoy postdoctoral fellowship
The Stériade-Savoy postdoctoral fellowship is awarded by the Savoy Foundation, one of Canada's only philanthropic organizations focused solely on epilepsy research.

21Apr
KCNhub member Dr. Frances Skinner talks with ConcussionTalk Podcast
Nick Mercer of ConcussionTalk chats with Dr. Frances Skinner

21Apr
KCNhub members Drs. Frances Skinner, Alexandra Chatzikalymniou, Scott Rich, Jeremie Lefebvre, and KCNhub alumnus Anton Lunyov publish new paper
This work builds on previously developed network models of the hippocampus to develop hypotheses of how the frequency of theta rhythms (associated with learning and memory) are controlled.

16Apr
Kramay Patel (KCNhub member) honoured with a U of T Award of Excellence
Graduate student Kramay Patel (BME MD/PhD candidate) is one of two engineering community members honoured by the University of Toronto with Awards of Excellence (AWEX).

15Apr
Computational Neuroscience Talk of interest by Dr. Michael Halassa
The following talk in the Physiology Department by Dr. Michael Halassa may be of interest to the KCNhub community as it involves computational neuroscience/modeling. Click "more info" for details!

14Apr
Inauguration of the Max Planck – University of Toronto Centre for Neural Science and Technology with co-Director Dr. Taufik Valiante (KCNhub member)
The inauguration of the Max Planck – University of Toronto for Neural Science and Technology will be held on April 14th, 2021.

8Apr
Computational Neuroscience Talk of interest by Dr. Frances Skinner (KCNhub member)
The following talk in the 'Neurowire Virtual Club' by Dr. Frances Skinner may be of interest to the KCNhub community given its focus on computational neuroscience.

30Mar
Krembil Neuroinformatics Talk of interest by Dr. Petra Ritter
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.


22Feb
Krembil Neuroinformatics Talk of interest by Dr. Joana Cabral
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

19Feb
Mathematical Neuroscience Talk of interest by Dr. Afroditi Talidou (KCNhub member)
The following talk in an Applied Math workshop by Dr. Afroditi Talidou may be of interest to the KCNhub community given its focus on computational neuroscience. Click "more info" for details!

8Feb
Computational Neuroscience Talk of interest by Dr. Peter Dayan
The following talk via Fields/Machine Learning Advances and Applications Seminar may be of interest to the KCNhub community given its focus on computational neuroscience. Pre-registration required.

20Jan
Krembil Neuroinformatics Talk of interest by Dr. Lori Chibnik
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

14Jan
Computational Neuroscience Talk of interest by Dr. Milad Lankarany (KCNhub member)
The following talk in the Physiology Department by Dr. Milad Lankarany may be of interest to the KCNhub community given its focus on computational neuroscience. Click "more info" for details!

5Jan
KCNhub members Drs. Scott Rich and Milad Lankarany and collaborators publish new paper
Drs. Rich and Lankarany and collaborators have distilled the lessons learned from creating and organizing the Canadian Computational Neuroscience Spotlight into "Ten Simple Rules" for creating a virtual academic meeting, published in PLOS Computational Biology.

16Dec
Krembil Neuroinformatics Talk of interest by Dr. Frances Skinner (KCNhub member)
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

10Dec
Computational Neuroscience Talk of interest by Dr. Sean Hill
The following talk in the Physiology Department by Dr. Sean Hill may be of interest to the KCNhub community given its focus on computational neuroscience. Click "more info" for details!

23Nov
Krembil Neuroinformatics Talk of interest by Dr. Stephanie Jones
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

16Nov
KCNhub member Dr. Scott Rich publishes in the ORT Times
Dr. Rich provides tips for fellowship writing in his newest piece for the ORT Times.

3Nov
KCNhub member Dr. Taufik Valiante takes on Directorship of The CRANIA Neuromodulation Institute
Congratulations to neurosurgeon & Krembil scientist Dr Valiante, who will take on the new role of Director of The CRANIA Neuromodulation Institute (CNMI). The goal of the CNMI is to advance the field of neuromodulation in Canada, through collaboration.

3Nov
KCNhub member Dr. Taufik Valiante on today's UHN podcast Behind the Breakthrough
On today's episode of @UHN's Behind the Breakthrough Podcast, CRANIA co-founder Dr Valiante discusses the implantable computer chip he invented to prevent seizures, burnout in healthcare workers, and achieving mental wellness.

27Oct
Krembil Neuroinformatics Talk of interest by Dr. Philip De Jager
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

27Oct
KCNhub member Alexandra Chatzikalymniou to present at Neuromatch 3.0 virtual conference
Title: On the generation of theta rhythms and theta-gamma phase amplitude coupling. Authors: Alexandra Chatzikalymniou; Frances K Skinner. Neuromatch 3.0 virtual conference persention time: Oct 27, 2:30 PM.

22Oct
KCNhub member Alexandra Chatzikalymniou to present at FIP2020
State-of-the-art, biophysical models of the CA1 region of the hippocampus reveal how theta rhythms are generated and how their frequencies are controlled.

19Oct
KCNhub members Drs. Scott Rich, Homeira Moradi Chameh, Taufik Valiante, Frances Skinner and KCNhub alumnus Dr. Vladislav Sekulic publish new paper
This work presents the development of a novel human cell model of a L5 pyramidal cortical cell. It is used to show that particular biophysical ion channel differences between human and rodent can be responsible for dynamical response differences.

14Oct
KCNhub alumnus Dr. Alexandre Guet-McCreight and KCNhub member Dr. Frances Skinner and collaborators publish new paper
This study describes particular physiological changes in inhibitory interneurons, but not in their numbers and morphologies, during aging. These changes are correlated with learning and memory deficits that occur with age.

2Oct
KCNhub members David Crompton and Shakiba Tonekabonipour receive Mitacs Research Training Awards
Congratulations! David Crompton and Shakiba Tonekabonipour have been awarded Mitacs Research Training Awards for Fall 2020 working with KCNhub member Dr. Milad Lankarany.

2Oct
KCNhub members Mohammad Rezaei and Dr. Milad Lankarany and collaoborator publish new paper
This new work shows that the amount of information that differentially correlated spikes in a neural ensemble carry is not the same; the information of different types of spikes is associated with different features of the stimulus.

25Sep
Krembil Neuroinformatics Talk of interest by Dr. John Murray
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

25Sep
World Wide Neuro talks of interest by Profs Henning Sprekeler and Rishidev Chaudhuri
The following talks may be of interest to KCNhubbers and the computational neuroscience community. It is part of the ongoing online neuroscience World Wide Neuro talks - see 'Resources' tab of kcnhub.com

25Sep
KCNhub members Daniel Park and Dr. Jeremie Lefebvre publish new paper
This work describes Important mathematical breakthroughs to better understand white matter plasticity

21Sep
KCNhub members Drs. Scott Rich, Jeremie Lefebvre, Taufik Valiante and Frances Skinner, along with collaborator Dr. Axel Hutt, publish new paper
This new research uses both computational and mathematical investigations to provide a fundamental mechanism underlying the anti-ictogenic role of noise in neural networks, as well as novel proposals for optimizing the efficacy of neurostimulation in the treatment of epilepsy.

17Sep
KCNhub member Dr. Frances Skinner with KCNhub alumni Drs. Vladislav Sekulic and Alexandre Guet-McCreight and collaborators publish new paper
This work shows that a tight integration of model and experiment can help tackle the challenge of characterizing biophysical details and distributions in spatially extended neurons. Here, we specifically characterized h-channel properties and showed that they must be present in the dendrites of OLM cells.

14Sep
World Wide Neuro Talks of interest this week (sept 15-18) by Shreejoy Tripathy, Christophe Benard, David McCormick, Gord Fishell, Julijana Gjorgjieva
The following talks may be of interest to KCNhubbers and the computational neuroscience community. It is part of the ongoing online neuroscience World Wide Neuro talks - see 'Resources' tab of kcnhub.com

10Sep
KCNhub member Alireza Ghadimi receives AGE-WELL-UofT FASE Award in Technology and Aging
Congratulations! Alireza Ghadimi has been awarded an AGE-WELL-UofT FASE Graduate Student and Postdoctoral Award in Technology and Aging for 2020-21.

8Sep
KCNhub member Dr. Scott Rich receives inaugural Yuet Ngor Wong Award
Congratulations! Dr. Scott Rich has been awarded an inaugural Yuet Ngor Wong Award for the 2020-2021 academic year on behalf of the Department of Physiology and the Centre for Mathematical Medicine at the Fields Institute.

8Sep
KCNhub member Dr. Scott Rich publishes in the ORT Times
Dr. Rich details the importance of communication in working with multiple supervisors on an interdisciplinary research project in his newest piece for the ORT Times.

25Aug
Krembil Neuroinformatics Talk of interest by Dr. Justin Baker
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at the Krembil Center for Neuroinformatics (KCNI) at CAMH.

19Aug
World Wide Neuro talk of interest by Dr. Alfredo Gonzalez-Sulser
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It is part of the ongoing online neuroscience World Wide Neuro talks - see 'Resources' tab.

7Aug
Center for Mathematical Medicine Seminar of interest by Dr. Jonathan Rubin
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It is part of the Fields/CMM seminar series - see 'Training' tab.

7Aug
KCNhub member Dr. Milad Lankarany, Navid Hasanzadeh and Mohammadreza Rezaei, KCNhub alumnus Sayan Faraz and collaborator publish new paper
Necessary conditions for reliable propagation of the time-varying firing rate across multiple layers of feed-forward neural networks were explored. This work is related to the concepts of stochastic resonance & system-size coherence resonance.

5Aug
World Wide Neuro Talk of interest by Dr. Peyman Golshani
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It is part of the ongoing online neuroscience World Wide Neuro talks - see 'Resources' tab.

24Jul
Krembil Neuroinformatics Talk of interest by Dr. Gaute Einevoll
The following talk may be of interest to KCNhubbers and the computational neuroscience community. It continues a speaker series at KCNI - will be posted on 'Resources' tab when it becomes available.

21Jul
KCNhub member Dr. Frances Skinner to present at the CNS2020 Online Meeting
Workshop entitled: Dissecting the role of interneurons in mnemonic functions using computational modelling approaches

21Jul
KCNhub member Dr. Jeremie Lefebvre publishes (again) in 'The Conversation'
Neurostimulation may herald a new treatment for depression - as written in The Conversation - an independent source of news and views, from the academic and research community, delivered direct to the public.

20Jul
KCNhub member Alireza Ghadimi to present at the CNS2020 Online Meeting
Inferring parameters of DBS-induced short-term synaptic plasticity from in-vivo recordings of human brain

20Jul
KCNhub alumnus Dr. Alexandre Guet-McCreight to present at the CNS2020 Online Meeting
Computationally Going Where Experiments Cannot: A Dynamical Assessment of Dendritic Currents in the Behaving Animal

20Jul
KCNhub member Dr. Scott Rich to present at the CNS2020 Online meeting
Dr. Scott Rich will present research performed with fellow KCNhub members Drs. Frances Skinner, Taufik Valiante and Jeremie Lefebvre investigating the mathematical underpinnings of the anti-ictogenic effects of high-frequency noisy and periodic neurostimulation in model neural microcircuits. Click the following link to see his poster and the links to the presentation itself.

20Jul
KCNhub alumnus Rabiya Noori to present at the CNS2020 Online Meeting
Adaptive activity-dependent myelination promotes synchronization in large-scale brain network

20Jul
KCNhub member Daniel Park to present at the CNS2020 Online Meeting
Synchronization and resilience in the Kuramoto white matter network model with adaptive state-dependent delays

18Jul
KCNhub members Drs. Milad Lankarany and Idir Mellal to present at IEEE Engineering in Medicine and Biology Society Workshop
Workshop entitled: Advances in Wearable Technology and Biomedical Devices: Opportunities and Challenges

17Jul
KCNhub member Jack Zhenyang Sun receives NSERC Undergraduate Student Research Award
NSERC USRA awarded to Jack working in Dr. Frances Skinner's Lab. Project entitled, "Capturing Biophysical Dynamics in Reduced Models of Hippocampal Interneurons".

15Jul
KCNhub member Dr. Jeremie Lefebvre publishes in 'The Conversation'
Our brains communicate information in a manner that can be likened to an air traffic controller - as written in The Conversation - an independent source of news and views, from the academic and research community, delivered direct to the public.

14Jul
KCNhub member Dr. Scott Rich publishes op-ed in Times Higher Education
In his second op-ed for Times Higher Education, Dr. Scott Rich discusses the risk that the "virtual academy" could become a "feedback loop" excluding young and early-career researchers, and the steps that should be taken not to leave out the next generation of academics.

13Jul
UHN news highlight of KCNhub research - Lefebvre Lab
The research of KCNhub members and collaborators to understand “brain infrastructure” via mathematical modeling was highlighted in a recent UHN research news write-up which can be found following the link below.

29Jun
Krembil Neuroinformatics One Year Celebration
The Krembil Center for Neuroinformatics is celebrating one year with a day of presentations.

29Jun
KCNhub member Dr. Milad Lankarany receives NSERC Discovery Grant
Grant Title: Uncovering biophysical and functional mechanisms of information processing in neural systems

29Jun
KCNhub member Dr. Taufik Valiante receives NSERC Discovery Grant
Grant Title: HuNeuD - The Human Neuron Discovery Program

25Jun
KCNhub alumnus Sayan Faraz and KCNhub members Drs. Idir Mellal and Milad Lankarany publish new paper
Multi-layered feedforward neural network (mlFNN) is thought of as a biologically-plausible architecture that transmits information from the upstream neurons to the downstream neurons. The impact of synaptic strength in the reliable propagation of asynchronous spikes in mlFNN is studied.

18Jun
Krembil Neuroinformatics talk of interest by Dr. Sean Hill
The following talk may be of interest to the computational neuroscience community. It is the start of a series of talks at KCNI - will be posted on 'Resources' tab when it becomes available.

17Jun
KCNhub members Yupeng Tian and Dr. Milad Lankarany, KCNhub alumnus Sara Taghizadeh Kakhki and collaborators publish new paper
The feasibility of ECG recordings from the waist was demonstrated using textile sensors. This study provides a foundation for the development of smart wearables like smart underwear for Heart Health Monitoring in a continuous, real-time, and non-invasive way.

15Jun
KCNhub member Dr. Jeremie Lefebvre with KCNhub alumni Rabiya Noori, Dr. John Griffiths, KCNhub member Daniel Park and collaborators publish new paper
This work suggests that adaptive myelination may be a mechanism that enables brain networks with a means of temporal self-organization, resilience, and homeostasis.

10Jun
KCNhub member Dr. Frances Skinner and collaborators receive New Frontiers in Research Fund - Exploration Grant
Grant Title: Merging Mathematical Models and Experimental Data of Brain Rhythms to Identify Cell-Specific Pathways Modified in Brain Injury Disease States

9Jun
KCNhub alumnus Dr. Alexandre Guet-McCreight, KCNhub member Dr. Frances Skinner and collaborator publish new paper
Everything you wanted to know about interneuron-specific cells but were afraid to ask!

4Jun
KCNhub member Dr. Scott Rich publishes the second piece in his "Interdisciplinary Research" series for the Academic Chatter Blog
The second piece in Scott's blog series, charting his path to a career in Interdisciplinary Research, can be found by clicking the following link.

4Jun
KCNhub members Chaim Katz, Kramay Patel, Dr. Taufik Valiante and collaborators publish new paper
For memory/hippocampus aficionados - saccades and image onset responses are very different - something to keep in mind when designing visual memory tasks.

28May
KCNhub members Dr. Marjan Rafiee, Kramay Patel, Dr. Taufik Valiante and collaborators publish new paper
In this one year intervention it was shown daily listening to Mozart K.448 can reduce seizures frequency in individuals with epilepsy, in comparison with a carefully selected control piece lacking rhythmicity.

27May
KCNhub member Dr. Jeremie Lefebvre to present at Neuromatch 2.0 virtual conference
Dr. Jeremie Lefebvre will present his research on adaptive myelination, white matter plasticity and synchrony during the 1 pm parallel "short talks" session of the Neuromatch 2.0 conference. More details can be found via the following link.

26May
KCNhub member Dr. Scott Rich to present at Neuromatch 2.0 virtual conference
Dr. Scott Rich will present his research, "Modeling reveals human-rodent differences in h-channel kinetics influencing resonance in cortical layer 5 neurons", during the 7 pm parallel "short talks" session of the Neuromatch 2.0 conference. More details can be found via the following link.

7May
Keyfitz Lecture in Mathematics and the Social Sciences by Wendy K. Tam Cho
This annual Fields lecture may be of interest to the KCNhub community, and can be accessed via the link below.

1May
KCNhub member Dr. Scott Rich publishes his first piece as an "ORT Times Science Writer"
Scott will be contributing pieces to the Office of Research Trainees' monthly newletter, the "ORT Times", approximately bimonthly. You can read his first piece, outlining some important tips for working from home, by following the "more info" link.

15Apr
"Neurotheory" virtual talk of interest by Dr. Andre Longtin
This talk by Dr. Andre Longtin may be of interest to the KCNHub community, and can be accessed via the link below. It is part of an ongoing series of “Neurotheory World” virtual talks.

13Apr
UHN news highlight of KCNhub research - Skinner Lab
The research of KCNhub members and collaborators to “map out memory” via mathematical modeling was highlighted in a recent UHN research news write-up which can be found following the link below.

17Mar
KCNhub alumnus Dr. Alexandre Guet-McCreight and KCNhub member Dr. Frances Skinner publish new paper
This computational study takes advantage of our detailed multi-compartment models to investigate dendritic ion channel biophysics.

5Mar
Focus Program on New Geometric Methods in Neuroscience
This program at the Fields Institute may be of interest to the KCNhub community. Event is ongoing from Feb 24 to March 13.

27Feb
Computational Neuroscience Talk of interest by Dr. Shreejoy Tripathy
The following talk in the Physiology Department by Dr. Shreejoy Tripathy may be of interest to the KCNhub community given its focus on computational neuroscience. Click "more info" for details!

21Feb
KCNhub alumnus Dr. Alexandre Guet-McCreight, KCNhub member Dr. Frances Skinner and collaborators publish new paper
This new research combines computational and experimental work to understand disinhibition mechanisms in the hippocampus

21Jan
KCNhub member Dr. Jeremie Lefebvre and collaborators publish new paper
This new research examines the role played by noise in dictating coherent brain dynamics.

14Jan
KCNhub members Drs. Scott Rich, Marjan Rafiee, Frances Skinner, Taufik Valiante, KCNhub alumnus Dr. Katie Ferguson and collaborator publish new paper
This new research posits a computational mechanism underlying the increased activity of interneurons seen prior to seizure initiation.

4Dec
Dr. Scott Rich publishes opinion piece in Times Higher Education.
The reach of KCNHub is extending into the realm of scientific communication! Dr. Scott Rich recently published an opinion piece in Times Higher Education discussing both the benefits and drawbacks of how social media, specifically Twitter, is used amongst academics. You can read the piece here.