https://www.engineering.utoronto.ca/2024-2026-joint-emhseed-xseed-grant-recipients-announced/
Title: Enhancing Closed-Loop Noninvasive Neurostimulation with Neuroimaging and Personalized Whole-Brain Neurophysiological Modelling
Co-Applicants: Milad Lankarany (BME) & John Griffiths (Psychiatry)
Repetitive transcranial magnetic stimulation (rTMS) is an important and rapidly developing therapeutic option for patients with major depressive disorder, addiction, OCD, and several other psychiatric and neurological conditions. However, with remission rates ranging from 40-60%, there is room for improvement in clinical outcomes. Drawing on Lankarany and Griffith’s expertise in these two areas, this project will develop and test a new suite of algorithmic tools designed to enhance rTMS efficacy. This will be achieved by controlling stimulation pulse timing in a manner that is more accurately tuned and responsive to the brain’s own intrinsic rhythmic patterns, as measured by high-density scalp electroencephalography (EEG).