Luka Milosevic

Luka Milosevic received his PhD in Biomedical Engineering from the University of Toronto, after which he pursued a Postdoctoral Fellowship at University of Tübingen Institute for Neuromodulation and Neurotechnology, Germany. He is currently a Scientist at the Krembil Research Institute, Assistant Professor at the University of Toronto Institute of Biomedical Engineering, and an Affiliate Scientist at the KITE Research Institute, and co-Director of the Center for Advancing Neurotechnological Innovation to Application (CRANIA). Dr. Milosevic also plays a clinical role monitoring patients’ brain activity to guide the placement of deep brain stimulation (DBS) devices at the Toronto Western Hospital. His research is at the intersection of biomedical engineering and human neurophysiology and the focus of his program is on the development of novel data-driven methods of neuromodulation and brain stimulation. His lab specializes in intracranial and whole-brain neurophysiological recordings in people with brain disorders, and optical, electrophysiological, and behavioural techniques in preclinical models.
  • Scientist, Krembil Brain Institute, Division of Clinical and Computational Neuroscience, Krembil Research Institute, University Health Network (UHN)
  • Assistant Professor, Institute of Biomedical Engineering, University of Toronto
  • Affiliate Scientist, The KITE Research Institute, UHN
  • Scientific Coordinator, Max Planck-University of Toronto Center for Neural Science and Technology
  • Co-Director, Center for Advancing Neurotechnological Innovation to Application (CRANIA), UHN.
  • Dr. Milosevic’s Translational Neurophysiology and Brain Stimulation (TNBS) lab leverages biomedical signal processing, machine learning, and computational modelling techniques in the context of in vivo brain research. The main interests of the lab include neurophysiological mechanisms of action of deep brain stimulation, synaptic plasticity, and pathophysiological processes in Parkinson’s disease and other neurological disorders. The lab works with human brain recording modalities across a range of spatial and temporal resolutions (ex. single-neuron recordings, local field potentials, ECoG, MEG), and state of the art preclinical techniques including optogenetics, fiber photometry, and high-density electrophysiology
  • Steiner LA, Crompton D, Sumarac S, Scherer M, Vetkas A, Germann J, Popovic MR, Kalia SK, Hodaie M, Hutchison WD, Lozano AM, Lankarany M, Kühn AA, Milosevic L. Neural signatures of indirect pathway activity in Parkinson’s disease. Nature Communications. 2024 Apr 11;15(1):3130.
  • Scherer M, Harmsen IE, Samuel N, Germann J, Elias GJB, Giacobbe P, Rowland NC, Lozano AM, Milosevic L. Oscillatory network markers of subcallosal cingulate deep brain stimulation for depression. Brain Stimulation. 2023 Nov 1;16(6):1764-75.
  • Neumann WJ, Steiner LA, Milosevic L. Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions. Brain. 2023 Nov;146(11):4456-68.
  • Steiner LA, Milosevic L. A convergent subcortical signature to explain the common efficacy of subthalamic and pallidal deep brain stimulation. Brain Communications. 2023 Apr 1;5(2):fcad033.
  • Scherer M, Steiner LA, Kalia SK, Hodaie M, Kühn AA, Lozano AL, Hutchison WD, Milosevic L. Single-neuron bursts encode pathological oscillations in Parkinson’s disease and essential tremor. Proceedings of the National Academy of Sciences. 2022 Aug 30;119(35):e2205881119.
  • Sumarac S, Spencer KA, Steiner LA, Scherer M, Kalia SK, Hodaie M, Lozano AL, Hutchison WD, Kühn AA, Milosevic L. Interrogating basal ganglia circuit function in Parkinson’s disease and dystonia. eLife. 2024;12.
  • Sumarac S, Youn J, Fearon C, Scherer M, Al-Ozzi T, Haniff E, Flouty O, Hodaie M, Popovic MR, Kalia SK, Lozano AM, Hutchison WD, Fasano A, Milosevic L. Clinico-physiological correlates of Parkinson’s disease from multi-resolution basal ganglia recordings. npj Parkinson’s disease. 2024 Sep 12;10(1):175.
Jeremie Lefebvre

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