Luka Milosevic

Luka Milosevic received his PhD in Biomedical Engineering from the University of Toronto, after which he pursued a Postdoctoral Fellowship at University of Tübingen Institute for Neuromodulation and Neurotechnology, Germany. He is currently a Scientist at the Krembil Research Institute, Assistant Professor at the University of Toronto Institute of Biomedical Engineering, and an Affiliate Scientist at the KITE Research Institute. Dr. Milosevic also plays a clinical role monitoring patients’ brain activity to guide the placement of deep brain stimulation (DBS) devices at the Toronto Western Hospital. His research is at the intersection of biomedical engineering and human neurophysiology and the focus of his program is on the development of novel data-driven methods of brain stimulation to treat individuals with neurological disorders.

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• Scientist, Krembil Brain Institute, Division of Clinical and Computational Neuroscience, Krembil Research Institute, University Health Network (UHN)
• Assistant Professor, Institute of Biomedical Engineering, University of Toronto
• Affiliate Scientist, The KITE Research Institute, UHN
• Scientific Coordinator, Max Planck-University of Toronto Center for Neural Science and Technology

• Dr. Milosevic’s Translational Neurophysiology and Brain Stimulation (TNBS) lab leverages biomedical signal processing, machine learning, and computational modelling techniques in the context of in vivo human brain research. The main interests of the lab include neurophysiological mechanisms of action of deep brain stimulation, in vivo synaptic plasticity, and pathophysiological processes in Parkinson’s disease and other neurological disorders. The lab works with human brain recording modalities across a range of spatial and temporal resolutions (ex. single-neuron recordings, local field potentials, ECoG, MEG).

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• Milosevic L, Kalia SK, Hodaie M, Lozano AM, Fasano A, Popovic MR, Hutchison WD. Neuronal inhibition and synaptic plasticity of basal ganglia neurons in Parkinson's disease. Brain. 2018 Jan 1;141(1):177-90
• Milosevic L, Kalia SK, Hodaie M, Lozano AM, Popovic MR, Hutchison WD. Physiological mechanisms of thalamic ventral intermediate nucleus stimulation for tremor suppression. Brain. 2018 Jul 1;141(7):2142-55
• Milosevic L, Gramer R, Kim TH, Algarni M, Fasano A, Kalia SK, Hodaie M, Lozano AM, Popovic MR, Hutchison WD. Modulation of inhibitory plasticity in basal ganglia output nuclei of patients with Parkinson's disease. Neurobiology of disease. 2019 Apr 1;124:46-56
• Milosevic L, Scherer M, Cebi I, Guggenberger R, Machetanz K, Naros G, Weiss D, Gharabaghi A. Online Mapping with the Deep Brain Stimulation Lead: A Novel Targeting Tool in Parkinson's Disease. Movement Disorders. 2020 May 18
• Scherer M, Milosevic L, Guggenberger R, Maus V, Naros G, Grimm F, Bucurenciu I, Steinhoff BJ, Weber YG, Lerche H, Weiss D. Desynchronization of temporal lobe theta-band activity during effective anterior thalamus deep brain stimulation in epilepsy. NeuroImage. 2020 May 20:116967
• Milosevic L, Kalia SK, Hodaie M, Lozano AM, Popovic MR, Hutchison WD, Lankarany M. A theoretical framework for the site-specific and frequency-dependent neuronal effects of deep brain stimulation. Brain Stimulation. 2021 Jul 1;14(4):807-21