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Jérémie Lefebvre

Jeremie Lefebvre is an Associate Faculty of the Department of Biology of the University of Ottawa and an Affiliate Scientist at the Krembil Research Institute. He is also an Assistant Professor in Department of Mathematics and Institute for Biomaterials and Biomedical Engineering of the University of Toronto. During his doctoral and postdoctoral training, Prof Lefebvre worked in Ottawa, Nancy, Geneva and Lausanne, doing research on neuroscience, non-linear dynamics, bifurcation theory, probabilistic neural coding and cognitive neuroimaging. His team uses interdisciplinary methods to characterize fluctuations in brain activity to better understand their involvement in brain health and diseases, such as epilepsy, depression and multiple-sclerosis. He collaborates closely with international teams of experimentalists and clinicians in the fields of cognitive neuroscience, neuroimaging and brain stimulation. Prof. Lefebvre has supervised trainees from a wide spectrum of backgrounds (from mathematics to physiology) over the years, as well as across various levels (from undergrads to postdocs) and in diversified research environments (universities, hospitals, institutes).
  • Associate Professor | Department of Biology, University of Ottawa (primary)
  • Adjunct Scientist | Krembil Research Institute, University Health Network, Toronto
  • Assistant Professor | Department of Mathematics, University of Toronto
  • Assistant Professor (cross appointed) | Institute for Biomaterials and Biomedical Engineering (IBBME), University of Toronto
  • Jeremie Lefebvre’s scientific interests span non-linear dynamics, mathematical and computational biology as well as biomedical engineering. Specifically, he is interested in brain stimulation, neural coding, white matter, oscillatory neural activity, synchronization and self-organization in complex neural and biological systems.
  • Dahmen, D. et al. (2025). How heterogeneity shapes self-organized pattern formation and computation in the brain. Neuron (accepted).
  • Rich, S., Valiante, T., & Lefebvre, J. (2025). H- and m-channel overexpression promotes seizure-like events by impairing inhibitory processing. PLOS Computational Biology, 21(6), e1013199
  • Abeywardena, K. G., Lefebvre, J., Valiante, T., & Draper, S. C. (2025). Excitability heterogeneity and synaptic coupling shape resilience in a macro-scale network. PLOS Complex Systems, 2(7), e0000057.
  • Lefebvre, J., Clappison, A, Longtin, A., & Hutt, A. (2025). Myelin-induced gain control in nonlinear neural networks. Communications Physics, 8:145.
  • Sengupta, S., Talidou, A, Lefebvre, J., & Skinner, F.K. (2025). Cell-type-specific contributions to theta-gamma coupled rhythms in the hippocampus. Network Neuroscience, 1-25.
  • Hutt, A., Trotter, D., Pariz, A., Valiante, T., & Lefebvre, J. (2024). Diversity-induced trivialization and resilience of neural dynamics. Chaos, 34(1), 013147.
  • Hutt, A., Rich, S., Valiante, T., & Lefebvre, J. (2023). Intrinsic neural diversity quenches the dynamic volatility of balanced neural networks. PNAS, 120(28), e2218841120.
  • Pariz, A., Trotter, D., Hutt, A., & Lefebvre, J. (2023). Selective control of synaptic plasticity through tACS in heterogeneous networks. PLOS Computational Biology, 19(4), e1010736.
  • Talidou, A., Frankland, P., Mabbott, D., & Lefebvre, J. (2022). Homeostatic coordination and up-regulation of neural activity by activity-dependent myelination. Nature Computational Science, 2, 665–676.
  • Rich, S., Chameh, H., Lefebvre, J., & Valiante, T. (2022). Loss of neuronal heterogeneity in epileptogenic human tissue renders networks more susceptible to sudden synchrony shifts. Cell Reports, 39(8), 110863.
  • Lefebvre, J., Hutt, A., Fröhlich, F. (2017). Stochastic resonance mediates state-dependent effects of periodic stimulation on cortical alpha oscillations. eLife, e32054.
  • Hutt, A., Griffiths, J., Herrmann, C., & Lefebvre, J. (2018). Effect of stimulation waveform on nonlinear entrainment of cortical alpha oscillations. Frontiers in Neuroscience, 12, 376.
  • Bells, S., Lefebvre, J., Prescott, S., Dockstader, C., Bouffet, E., Skocic, J., Laughlin, S., & Mabbott, D. (2017). Changes in white matter microstructure disrupt synchronization and cognition. Journal of Neuroscience, 37(34), 8227–8238.

Computational neuroscience, non-linear dynamics, brain rhythms, synchronization, neural control, white matter plasticity, neuroprosthetics

Jeremie Lefebvre

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