Krembil Computational Neuroscience
Krembil Computational Neuroscience
Harnessing mathematical modeling and engineering to bridge theory and practice in neural health and diseases
KCNhub Mission Statement
Because science starts with human interactions.... we must hope for people with different cultures, expertise, perspectives and footwear to leave their prejudices at the door and learn to appreciate each others` strengths...
G. Laurent (Nature Neuroscience, 2000)
The future will depend on stronger quantitative understanding in our experimental community and better biology intuition in our theory community.
E Marder (PLoS Biology, 2015)
News and Info
27Feb
KCNhub member Dr. Jeremie Lefebvre and KCNhub alumnus Dr. Afroditi Talidou publish new paper
The study highlights the importance of spatial heterogeneity of myelin sheathing in shaping nerve axonal conduction. Using model axons that faithfully replicate myelin distributions observed in the mouse central nervous system, our results revealed the impact of myelin patterns on the timing and reliability of neural signaling. Contrary to the conventional view in which uniform and equally spaced myelin segments imply linear conduction, our findings show that axonal conduction is a path-dependent, nonlinear process influenced by the specific distribution of myelinated and unmyelinated segments. Membrane potential propagation along model axons in the corpus callosum was found to be more vulnerable to myelin changes compared to those in the cortex, especially post-myelin injury, emphasizing the role of sheath locations in both health and disease.
27Feb
Krembil Brain Institute (KBI) zoom talk by KCNhub member Dr. Maurizio De Pitta
Maurizio will speak (via zoom) at the launch of the Computational and Clinical Neuroscience lecture series on Thursday Feb 27th at 8am.
6Mar
Krembil Brain Institute (KBI) zoom talk by KCNhub member Dr. Milad Lankarany
Milad will speak (via zoom) at the Computational and Clinical Neuroscience lecture series on Thursday March 6th at 8am.
10Apr
EMBO Course on Quantifying Astrocyte Physiology by Models from Genome to Circuits
KCNhub member Maurizio De Pittà is speaker and curator for this EMBO Meeting Satellite event on April 10–11, 2025 at the University of Padua, Padua, Italy
14Apr
EMBO Workshop on Astrocytes: From Molecules to Systems
KCNhub member Maurizio De Pittà will be a speaker at this EMBO Workshop which is the first international meeting dedicated to astrocytes. It will take place at the Venice International University on San Servolo Island in Venice (Italy) on April 14–18, 2025.
1Jul
Fields Institute Thematic Program on the Mathematics of Neuroscience
KCNhub and KCNI members (Griffiths, Lefebvre, Skinner) are on the organizing committee for this program that will take place in 2025 (July to December).
Recent and Upcoming
27Feb
Role of astrocytes in sensorimotor integration in cortical and brainstem circuits
27 February 2025
13:00 - 14:00 PM
BMO Conference Center, Krembil Discovery Tower
Krembil Discovery Tower, 60 Leonard Avenue
Arlette Kolta (Montreal)
4Mar
Internal KCN - Functional electrical stimulation-therapy
4 March 2025
13:00 - 14:30 PM
4KD503
Mike Howard
11Mar
Internal KCN - computational neuromodulation
11 March 2025
13:00 - 14:30 PM
4KD503
Milad Lankarany
20Mar
On the Regulation of the Cerebral Circulation by Astrocytes
20 March 2025
13:00 - 14:00 PM
BMO Conference Center, Krembil Discovery Tower
Krembil Discovery Tower, 60 Leonard Avenue
Grant Gordon (Calgary)
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