Krembil Computational Neuroscience
Krembil Computational Neuroscience
.... it is unclear where the inflection point describing model complexity and increased understanding lies.
Gjorgjieva et al. (Current Opinion in Neurobiology, 2016)
The first thing to do is to clearly state the goal of the modeling...
Shou et al. (eLife, 2015)
Because science starts with human interactions.... we must hope for people with different cultures, expertise, perspectives and footwear to leave their prejudices at the door and learn to appreciate each others` strengths...
G. Laurent (Nature Neuroscience, 2000)
Simulation neuroscience is a catalyst for experimental neuroscience, not a replacement.
H. Markram (Neuroscience News and Research, 2020)
Global understanding, when it comes, will likely take the form of highly diverse panels loosely stitched together into a patchwork quilt
Churchland and Abbott (Nature Neuroscience, 2016)
...we should read the words on the page or screen, not the words in our head as we read papers by other scientists and try to make sure that our own papers capture our intent.
E Marder (eLife, 2020)
Neither ignore the details nor be consumed by them... the balance is the challenge in advancing our understanding.
Skinner and Mulloney (Current Opinion in Neurobiology, 1998)
The future will depend on stronger quantitative understanding in our experimental community and better biology intuition in our theory community.
E Marder (PLoS Biology, 2015)
Mathematics is biology`s next microscope.
JE Cohen (PLoS Biology, 2004)
Recent and Upcoming
23Apr
Internal KCN: ws.kcnhub info session
23 April 2024
09:30 - 11:00 AM
4KD505
David Crompton
30Apr
Internal KCN: Firing Rate Models for Controlling Parkinsonian and Essential Tremor Using Deep Brain Stimulation
30 April 2024
09:30 - 11:00 AM
4KD503
Yupeng Tian
1May
KCNhub members Zhenyang Sun and Yupeng Tian receive travel awards to attend CAN meeting
Zhenyang Sun working in Dr. Maurizio De Pittà's lab and Yupeng Tian working in Dr. Milad Lankarany's lab have obtained travel awards to attend the Canadian Neuroscience Meeting (CAN) in Vancouver on May 19-22 2024. Congratulations!
2May
KCNhub member Dr. Maurizio De Pittà receives NSERC Discovery Grant
Congratulations! Discovery Grant PLUS!
3May
KCNhub member Zhenyang Sun receives NSERC Scholarship Award
Congratulations! Zhenyang, working in Dr. De Pittà's lab, has received a CGS-D NSERC Scholarship Award.
6May
KCNhub alumnus Dr. Giulio Bonifazi and KCNhub member Dr. Maurizio De Pitta and colleagues publish new paper
A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity" in Neurobiology of disease. This is the first study to model Alzheimer's emergence revealing how nonlinear molecular interactions diversify risk vs. treatment options in the wake of the disorder.
7May
Collective dynamics of large-scale spiking neural networks by mean-field theory
7 May 2024
09:30 - 11:00 AM
4KD503
Liang Chen (Waterloo)
8May
NYC Talk of interest by KCNhub member Dr. Maurizio De Pitta
Talk presentation entitled "Neuron-Glial Molecular Switches Across The Cognitive Spectrum" is accessible via zoom
9May
KCNhub members Yupeng Tian, Drs. Leon Steiner, Luka Milosevic, Milad Lankarany and colleagues publish new paper
A model of the firing rate dynamics of the nuclei impacted by Deep Brain Stimulation (DBS). The model replicates human clinical data recorded during different DBS frequencies, and investigates the underlying mechanisms in terms of DBS-induced short-term synaptic plasticity.
10May
KCNhub members Yupeng Tian, Srikar Saradhi, Drs. Leon Steiner, Milad Lankarany and colleagues publish new paper
A model-based closed-loop control system of Deep Brain Stimulation (DBS). The closed-loop control is based on our biophysically-realistic model underlying the DBS-impacted neural circuits. The system uses the model to predict activities in electromyography (EMG), which is implemented in a closed-loop controller to automatically update the DBS frequencies.
13May
KCNhub members Dr. Leon Steiner, David Crompton, Srdjan Sumarac, Drs. Maximilian Scherer, Milad Lankarany, Luka Milosevic and colleagues publish new paper
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) produces an electrophysiological signature called evoked resonant neural activity (ERNA); a high-frequency oscillation that has been linked to treatment efficacy. However, the single-neuron and synaptic bases of ERNA are unsubstantiated. This study proposes that ERNA is a subcortical neuronal circuit signature of DBS-mediated engagement of the basal ganglia indirect pathway network.
24Jun
Minisymposium on Computational Neuroscience to be held at CAIMS Meeting
This year's Canadian Applied and Industrial Mathematics Society (CAIMS) Meeting will include a Computational Neuroscience minisymposium.
27Jun
Frontostriatal Computations in Learning and Choice: From Motor to Cognitive Decisions
27 June 2024
10:00 - 11:30 AM
4KD503
Krembil Discovery Tower, 60 Leonard Avenue
Michael Frank (Brown)
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